I am a molecular biologist interested in gene regulation and epigenetics, especially in cancers
N.C. Tolga EMRE, PhD Associate Professor Boğaziçi University Department of Molecular Biology and Genetics GenReg: Laboratory of Genome Regulation Kuzey Park Binasi No 320 , Etiler 34342 Istanbul/Turkey V: +90.212.3597559 F: +90.212.2872468 E: tolga.emre[a]boun.edu.tr W: http://mbg.boun.edu.tr/?q=en/node/56
Brief CV:
Associate Professor (April 2016 – present)
(Assistant Professor: 2014 – 2016; Research Assistant Professor (MBG-BRIDGE/TAM): 2011 – 2014)
Laboratory of Genome Regulation (GenReg)
Department of Molecular Biology and Genetics
Boğaziçi University, Istanbul, Turkey
Postdoctoral Fellow (2006-2010)
Lymphoid Malignancies Section (Laboratory of Louis M. Staudt)
National Cancer Institute (NCI)
National Institutes of Health (NIH), Bethesda, Maryland, MD, USA
Postdoctoral Fellow (Transitionary) (Spring 2005-Fall 2005)
Gene Expression & Regulation Program (Laboratory of Shelley L. Berger)
The Wistar Institute, Philadelphia, PA, USA
PhD in Cell and Molecular Biology (1999-2005)
• Graduate Program in Biology, U. of Pennsylvania, Philadelphia, PA, USA
• Gene Expression & Regulation Program (Laboratory of Shelley L. Berger)
The Wistar Institute, Philadelphia, PA, USA
“Reversible Histone Ubiquitylation In Genomic Regulation: The Roles Of Ubiquitin Proteases Ubp10 And Ubp8 in the Budding Yeast”
(PhD Thesis Study, 2001-2005)
MSc in Molecular Biology (1997-1999)
Bilkent University, Ankara, Turkey
“In vitro study of p53 – p33ING1 Interactions”
(MS Thesis Study, 1998-1999; Supervised by: Rengül Çetin-Atalay)
BSc in Molecular Biology and Genetics (1993-1997)
Boğaziçi University, Istanbul, Turkey
Teaching
BIO583: Cancer Genomics and Epigenomics (Multiple Semesters)
BIO501: Advanced Molecular Biology (Multiple Semesters)
BIO483: Mechanisms in Gene Regulation and Epigenetics (Multiple Semesters)
BIO407: Seminar (Multiple Semesters)
BIO241: Cell Biology (Multiple Semesters)
BIO104: General Biology II (Multiple Semesters) (Co-instructor)
BIO102: Cell and Molecular Biology II (Multiple Semesters)
BIO101: General Biology I (Spring 2012) (Co-instructor)
BIO310: Advanced Cell Biology (Multiple Semesters)(Co-instructor)
Research Articles:
U Sobhiafshar, B Çakici, E Yilmaz, N Yildiz Ayhan, L Hedaya, MC Ayhan, C Yerinde, YB Alankuş, HK Gürkaşlar, EN Firat-Karalar, NCT Emre. Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells. Mol Oncol. 2024 Jun 16. doi: 10.1002/1878-0261.13672. Epub ahead of print.
• T Ergünay, …, NCT Emre, U Şahin (2022) Sumoylation of Cas9 at Lysine 848 Regulates Protein Stability and DNA Binding. Life Science Alliance 5 (4) e202101078; doi: 10.26508/lsa.202101078
• A Weilemann, M Grau, T Erdmann, O Merkel, U Sobhiafshar, I Anagnostopoulos, M Hummel, A Siegert, C Hayford, H Madle, B Wollert-Wulf, I Fichtner, B Dörken, S Dirnhofer, S Mathas, M Janz, NCT Emre, A Rosenwald, G Ott, P Lenz, A Tzankov, G Lenz (2015) Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma. Blood, 125 (1): 124-132
• C Praetorius, C Grill, SN Stacey, AM Metcalf, DU Gorkin, KC Robinson, EV Otterloo, RSQ Kim, K Bergsteinsdottir, MH Ogmundsdottir, E Magnusdottir, PJ Mishra, SR Davis, T Guo, MR Zaidi, AS Helgason, MI Sigurdsson, PS Meltzer, G Merlino, V Petit, L Larue, SK Loftus, DR Adams, U Sobhiafshar, NCT Emre, WJ Pavan, R Cornell, AG Smith, AS McCallion, DE Fisher, K Stefansson, RA Sturm, E Steingrimsson (2013) A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway. Cell.155:1022-1033 PMID: 24267888
• L Lamy, VN Ngo, NCT Emre, AL Shaffer et al (2013) Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma. Cancer Cell. 23:435-449. PMID: 23541952
• Y Yang*, AL Shaffer*, NCT Emre*, M Ceribelli et al (2012) Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma. Cancer Cell. 21:723-37 (*: equal contribution) PMID:22698399.
• L Rui, NCT Emre, MJ Kruhlak, HJ Chung et al (2010) Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 18:590-605. PMID:21156283.
Preview in Cancer Cell: “Partners in Crime: Genes within an Amplicon Collude to Globally Deregulate Chromatin in Lymphoma”
• B Sayan, NCT Emre, MB Irmak, M Öztürk, R Çetin-Atalay (2009) Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly specific antibody. Hybridoma, 28:1-6 PMID: 19132896
• AL Shaffer, NCT Emre, L Lamy, VN Ngo, G Wright, W Xiao, J Powell, S Dave, X Yu, H Zhao, Y Zeng, B Chen, J Epstein, LM Staudt (2008) IRF4 addiction in multiple myeloma. Nature, 454: 226-31. PMCID:2542904. Editor’s summary
News and Views in Nature: “Cancer: An unexpected addiction”
• G Lenz, GW Wright, NCT Emre, H Kohlhammer et al (2008) Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A, 105:13520-5. PMCID:2533222
• NCT Emre, K Ingvarsdottir, A Wyce, A Wood, NJ Krogan, KW Henry, K Li, JF Greenblatt, R Marmorstein, A Shilatifard, SL Berger (2005) Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere proximal Sir2 association and gene silencing. Mol Cell, 17: 585-594. PMID:15721261.
News release: “Enzyme shown to help protect genomic stability”
• K Ingvarsdottir*, NJ Krogan*, NCT Emre*, A Wyce, JF Greenblatt, SL Berger (2005) H2B ubiquitin protease Ubp8 and Sgf11 are a discrete functional module within the S. cerevisiae SAGA complex. Mol Cell Biol, 25:1162-1172. (*: shared first authors) PMCID:544016
• KW Henry, A Wyce, W-S Lo, LJ Duggan, NCT Emre, C-F Kao, L Pillus, A Shilatifard, MA Osley, SL Berger (2003) Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev, 21:2648-63. PMCID:280615.
• H Santos-Rosa, R Schneider, AJ Bannister, J Sherriff, BE Bernstein, NCT Emre, SL Schreiber, J Mellor, and T Kouzarides (2002). Active genes are tri-methylated at K4 of histone H3. Nature, 419:407-411. PMID:12353038.
• WS Lo, L Duggan, NCT Emre, R Belotserkovskya, WS Lane, R Shiekhattar, SL Berger (2001) Snf1–a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science, 293:1142-6. PMID:11498592
Review/Methods Articles/Chapters:
• DJ Klionsky et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, 17(1):1-382. doi: 10.1080/15548627.2020.1797280
• NCT Emre (2018) Epigenetik ve Kanser, book chapter in Kanserin Moleküler Biyolojisi (Ed. Y Baran; Kısayol Yayıncılık)
• AL Shaffer, NCT Emre, PB Romesser, LM Staudt (2009) IRF4: Immunity. Malignancy! Therapy? Clin Cancer Res. 15:2954-61. PMCID:2790720.
• NCT Emre, SL Berger (2006) Histone post-translational modifications regulate transcription and telomeric silencing in S. cerevisiae. Ernst Schering Res Found Workshop, 57:127-53. PMID: 16568953
• NCT Emre, SL Berger (2004) Histone H2B Ubiquitylation and Deubiquitylation in Genomic Regulation. Cold Spring Harbor Symposia on Quantitative Biology, 69: 289-299. PMID:16117661
Theses:
Reversible Histone Ubiquitylation In Genomic Regulation: The Roles Of Ubiquitin Proteases Ubp10 And Ubp8 in the Budding Yeast. N. C. Tolga EMRE (University of Pennsylvania, Philadelphia, PA, USA, 2005) (PhD Thesis)
http://repository.upenn.edu/dissertations/AAI3179728/
In vitro study of p53 – p33ING1 Interactions. N. C. Tolga EMRE (Bilkent University, Ankara, TURKEY, 1999) (MS Thesis)